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MABF18

Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7

clone AB34_41.4H12.4A7, from mouse

Synonym(s):

interleukin 1, beta, catabolin, pro-interleukin-1-beta, IL-1 beta, IL1-BETA, preinterleukin 1 beta, interleukin-1 beta, Catabolin

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

AB34_41.4H12.4A7, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_000567

UniProt accession no.

P01584

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... IL1B(3553)

General description

Interleukin-1 (IL-1) is a cytokine that is thought to be connected to neurodegeneration and in central nervous system-mediated defense reactions to inflammation. Interleukin-1 beta (IL-1B) maintains mitogen-induced proliferation, IL-2 production and expression of IL-2R. IL-1 beta also seems to have the ability to boost the number of cells that move into the G1 phase of the cell cycle. IL-1 beta also has the capacity to stimulate apoptosis on normal human fetal membranes. IL-1 beta may play an important role in inflammation regulating cytokine networks.
~17 kDa observed

Immunogen

Full length recombinant protein corresponding to human Interleukin-1 beta.

Application

Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7 is an antibody against Interleukin-1 beta (IL-1B) for use in WB.
Luminex Assay Analysis: A previous lot was used by an independent laboratory in Luminex (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX).
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human Interleukin-1 beta recombinant protein
Evaluated by Western Blot in lysate from cells expressing human Interleukin-1 beta recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human Interleukin-1 beta recombinant protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-462; MABF22

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yugang Sun et al.
Journal of biochemical and molecular toxicology, 35(4), e22689-e22689 (2020-12-22)
The present study examines the chemopreventive role of [6]-gingerol, an active component of ginger, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis models. The HBP has been developed with an addition of 0.5% of DMBA to the HBP area three
Jianhua Liu et al.
Frontiers in physiology, 8, 611-611 (2017-10-11)
Objective: This study aimed to investigate the effect of osmotin on myocardial ischemia/reperfusion (I/R), as well as the underlying mechanisms. Methods:In vitro I/R injury model was established on rat cardiac myoblast H9c2 cells by oxygen and glucose deprivation followed by
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Tapias, V; Cannon, JR; Greenamyre, JT
Neurobiology of Aging null

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