MABD123
Anti-Osteocalcin Antibody, Clone 7D1.13
clone 7D1.13, from mouse
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Synonym(s):
Bone Gla protein, BGP, BGLAP, Gamma-carboxyglutamic acid-containing protein
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7D1.13, monoclonal
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... BGLAP(632)
General description
Osteocalcin is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Osteocalcin is often studied in the osteogenesis of embryonic and mesenchymal stem cells.
Immunogen
KLH-conjugated linear peptide corresponding to Human Osteocalcin.
Application
Detect Osteocalcin using this mouse monoclonal antibody, Anti-Osteocalcin Antibody, Clone 7D1.13 validated for use in IHC (Paraffin) & IHC (tissue).
Research Sub Category
Mesenchymal Stem Cells
Osteobiology
Mesenchymal Stem Cells
Osteobiology
Quality
Evaluated by Immunohistochemistry on human trabecular bone in a human bone biopsy.
Immunohistochemical Analysis: A 1:50 Dilution of this antibody detected osteocalcin on human trabecular bone in a human bone biopsy.
Immunohistochemical Analysis: A 1:50 Dilution of this antibody detected osteocalcin on human trabecular bone in a human bone biopsy.
Target description
~6 kDa calculated
Linkage
Replaces: MABD182
Physical form
Format: Purified
Analysis Note
Control
Human trabecular bone in a human bone biopsy.
Human trabecular bone in a human bone biopsy.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hao Cheng et al.
Acta biomaterialia, 69, 342-351 (2018-01-26)
The inorganic part of human bone is mainly composed of hydroxyapatite (HAP: Ca10(PO4)6(OH)2) and whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) minerals, where the WH phase occupies up to 20-35% of total weight. These two bone minerals have different crystal structures and physicochemical properties
Stylianos Kosmidis et al.
Cell reports, 25(4), 959-973 (2018-10-26)
Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the
Zhe Shi et al.
International journal of nanomedicine, 15, 9337-9353 (2020-12-03)
Autologous bone grafts are the gold standard for treating bone defects. However, limited bone supply and morbidity at the donor site restrict its extensive use. Therefore, developing bone graft materials as an alternative to autologous grafts has gained considerable attention.
Zhe Shi et al.
International journal of nanomedicine, 16, 5603-5619 (2021-08-26)
Given that autologous bone graft for bone defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic graft materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic materials that could integrate the
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