MABC200
Anti-APC Antibody, clone CC-1
clone CC-1, from mouse
Synonym(s):
Adenomatous polyposis coli protein, APC, Deleted in polyposis 2.5
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-APC Antibody, clone CC-1, clone CC-1, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CC-1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APC(324)
Analysis Note
Immunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.
Application
Anti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
General description
311 kDa calculated
Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.
Immunogen
Recombinant protein corresponding to human APC.
Physical form
Format: Purified
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Glia, 62(9), 1513-1529 (2014-05-28)
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Glia, 70(11), 2045-2061 (2022-06-29)
Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis (MS). Nonetheless, the dynamics of
Maria Traka et al.
Brain : a journal of neurology, 133(10), 3017-3029 (2010-09-21)
Adult-onset demyelinating disorders of the central nervous system represent the most common neurological abnormalities in young adults. Nevertheless, our understanding of disease pathogenesis and recovery in demyelinating disorders remains incomplete. To facilitate investigation into these processes, we have developed a
Bastian G Brinkmann et al.
Neuron, 59(4), 581-595 (2008-09-02)
Understanding the control of myelin formation by oligodendrocytes is essential for treating demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS. It is thus thought that NRG1/ErbB signaling also regulates CNS myelination
Qi-Yan Cai et al.
Anatomical record (Hoboken, N.J. : 2007), 292(4), 498-512 (2009-01-15)
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