MAB5512
Anti-Parkin Antibody, clone PRK8
ascites fluid, clone PRK8, Chemicon®
Sign Into View Organizational & Contract Pricing
All Photos(3)
Synonym(s):
Anti-AR-JP, Anti-LPRS2, Anti-PARK2, Anti-PDJ
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PRK8, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PARK2(5071)
Specificity
Parkin. The epitope recognizes by the monoclonal is between animo acids 399-465 of human parkin. The antibody shows no cross-reactivity with protein in extracts from parkin null mice.
Immunogen
Recombinant human parkin.
Application
Anti-Parkin Antibody, clone PRK8 is an antibody against Parkin for use in IP, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot. The antibody detects ~50 and ~44 kDa bands in mouse brain extracts. In human brain extracts the antibody reacts with ~50 and ~46 kDa. Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Physical form
Ascites fluid. Liquid. Contains no preservative.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh, DP; Nguyen, DT; Pulst-Korenberg, JB; Brice, A; Pulst, SM
Experimental neurology null
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.
Duplan, E; Sevalle, J; Viotti, J; Goiran, T; Bauer, C; Renbaum, P; Levy-Lahad, E; Gautier et al.
Journal of Molecular Cell Biology null
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; Safe, S; Abou-Sleiman et al.
Nature Cell Biology null
Fumika Koyano et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(8), 672-681 (2013-06-12)
PINK1 and PARKIN are causal genes for hereditary Parkinsonism. Recent studies have shown that PINK1 and Parkin play a pivotal role in the quality control of mitochondria, and dysfunction of either protein likely results in the accumulation of low-quality mitochondria
J Viotti et al.
Oncogene, 33(14), 1764-1775 (2013-05-07)
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service