MAB3402B
Anti-GFAP Antibody, Biotin Conjugate | MAB3402B
from mouse, biotin conjugate
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Synonym(s):
Glial fibrillary acidic protein, GFAP
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
biotin conjugate
antibody form
purified antibody
antibody product type
primary antibodies
clone
monoclonal
species reactivity
pig, mouse
species reactivity (predicted by homology)
porcine (based on 100% sequence homology), human (based on 100% sequence homology), chicken (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GFAP(2670)
General description
Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
Immunogen
Purified glial filament protein (Debus, E., et al. (1983) Differentiation. 25:193-203.)
Application
Anti-GFAP Antibody, Biotin Conjugate detects level of GFAP & has been published & validated for use in IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
Quality
Evaluated by Immunohistochemistry in mouse adult brain tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected GFAP in mouse adult brain tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected GFAP in mouse adult brain tissue.
Target description
50 kDa calculated
Physical form
Protein A purified
Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage and Stability
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Analysis Note
Control
Mouse adult brain tissue
Mouse adult brain tissue
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Guo-Qiang Wang et al.
Journal of neuroscience research, 100(10), 1908-1920 (2022-07-08)
The glymphatic system is a recently discovered glial-dependent macroscopic interstitial waste clearance system that promotes the efficient elimination of soluble proteins and metabolites from the central nervous system. Its anatomic foundation is the astrocytes and aquaporin-4 (AQP4) water channels on
Thomas E Mahan et al.
Molecular neurodegeneration, 17(1), 13-13 (2022-02-04)
One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD and has been shown to
Monica Xiong et al.
Science translational medicine, 13(581) (2021-02-19)
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and greatly influences the development of amyloid-β (Aβ) pathology. Our current study investigated the potential therapeutic effects of the anti-human
Chao Wang et al.
Neuron, 109(10), 1657-1674 (2021-04-09)
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease and directly influences tauopathy and tau-mediated neurodegeneration. ApoE4 has strong deleterious effects on both parameters. In the brain, apoE is produced and secreted primarily by astrocytes
Avital Licht-Murava et al.
Science advances, 9(16), eade1282-eade1282 (2023-04-19)
Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in dementia, but the cell type-specific effects of TDP-43 pathology are not clear, and therapeutic strategies to alleviate TDP-43-linked cognitive decline are lacking. We found that patients with Alzheimer's
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