MAB312-AF647
Anti-A2B5 Antibody, clone A2B5-105 Antibody, Alexa Fluor™ 647 Conjugate
clone A2B5-105, from mouse, ALEXA FLUOR™ 647
Synonym(s):
F12A2B5, 105
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 647
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
A2B5-105, monoclonal
species reactivity (predicted by homology)
mammals
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
isotype
IgM
shipped in
ambient
target post-translational modification
unmodified
Related Categories
General description
A2B5 (also known as F12A2B5) is a cell surface ganglioside expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells. It is highly expressed in embryonic and neonatal tissue, but in the adult mammalian brain its expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ). Hence, A2B5 is considered as a marker for immature glial-committed precursors, which are permanently generated in the SVZ. Its expression is also considered as a marker for various cancers, including astrocytoma, glioma, pancreatic islet tumors, and squamous cell carcinoma. Explants from A2B5+ tumor cells display a typical progenitor morphology and clearly indicate their immature state. Tumors expressing A2B5 antigen exhibit higher rates of recurrence.
Specificity
This monoclonal antibody detects A2B5 in mammalian cells.
Immunogen
Embryonic chicken retinal cells.
Application
Anti-A2B5 Antibody, clone A2B5-105, Alexa Fluor™ 647 Conjugate Cat. No. MAB312-AF647, is a highly specific mouse monoclonal antibody that targets A2B5 and has been tested in Immunocytochemistry and Flow Cytometry.
Flow Cytometry Analysis: 1:400 dilution from a representative lot immunostained the surface of PC12 cells.
The unconjugated antibody (Cat. No. MAB312) is also available for flow cytometry, immunocytochemistry, immunofluorescence, and immunohistochemistry applications.
The unconjugated antibody (Cat. No. MAB312) is also available for flow cytometry, immunocytochemistry, immunofluorescence, and immunohistochemistry applications.
Quality
Evaluated by immunocytochemistry of PC12 cells.
Immunocytochemistry Analysis: A 1:100 Dilution of this antibody immunostained the surface of PC12 cells.
Immunocytochemistry Analysis: A 1:100 Dilution of this antibody immunostained the surface of PC12 cells.
Physical form
Purified mouse IgM Alexa Fluor™ 647 conjugate in PBS with 1.5% BSA and 0.05% sodium azide.
Other Notes
Concentration: Please refer to lot specific datasheet.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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WGK
WGK 2
Regulatory Information
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Certificates of Analysis (COA)
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