MAB1974
Anti-Integrin β3 Antibody, clone BB10
clone BB10, Chemicon®, from mouse
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Synonym(s):
CD61
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BB10, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
suitability
not suitable for immunohistochemistry (Paraffin)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGB3(3690)
Specificity
Reacts with the beta-3 subunit of the integrin family, including GPIIIa of platelets. Recognized an extracellular epitope of beta-3.
Immunogen
Partially purified platelet glycoprotein IIb/lIIa complex.
Application
Anti-Integrin β3 Antibody, clone BB10 is an antibody against Integrin β3 for use in WB, IC, IH.
Immunoblotting: 1:1000 (Ylanne et al., 1988, 1990). The antibody is most effective when used against non-reduced samples.
immunohistochemistry (indirect immunofluorescence)1:200 - 1:400. (Ylanne et al., 1988).
Does not work on paraffin embedded sections.
Final working dilutions must be determined by end user.
immunohistochemistry (indirect immunofluorescence)1:200 - 1:400. (Ylanne et al., 1988).
Does not work on paraffin embedded sections.
Final working dilutions must be determined by end user.
Physical form
Format: Purified
Purified immunoglobulin. In PBS with 1% BSA and 0.1% sodium azide.
Storage and Stability
Maintain between 2 and 8°C up to 12 months.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
recommended
Product No.
Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Gwendolyn F Elphick et al.
Blood, 113(17), 4078-4085 (2009-02-27)
Integrin-mediated cell migration is central to many biologic and pathologic processes. During inflammation, tissue injury results from excessive infiltration and sequestration of activated leukocytes. Recombinant human activated protein C (rhAPC) has been shown to protect patients with severe sepsis, although
D Seger et al.
The Journal of biological chemistry, 276(20), 16998-17006 (2001-03-30)
Phosphorylation of vitronectin (Vn) by casein kinase II was previously shown to occur at Thr50 and Thr57 and to augment a major physiological function of vitronectin-cell adhesion and spreading. Here we show that this phosphorylation increases cell adhesion via the
M A Scragg et al.
Infection and immunity, 67(4), 1837-1843 (1999-03-20)
Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In this study we examined the effects of Porphyromonas gingivalis proteases on human gingival
Franco Klingberg et al.
The Journal of cell biology, 207(2), 283-297 (2014-10-22)
Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the extracellular matrix (ECM). Mechanical activation of TGF-β1 is currently understood as an acute process that
John C Morrison
Transactions of the American Ophthalmological Society, 104, 453-477 (2007-05-02)
To demonstrate that specific distributions of integrin-based focal mechanoreceptors exist in primate optic nerve heads, suitable for translating stress and strain into the cellular responses of glaucomatous optic neuropathy. Normal human (N = 20) and rhesus monkey (N = 14)
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