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Merck
CN

MAB1954

Anti-Integrin α4 Antibody, clone P4G9

ascites fluid, clone P4G9, Chemicon®

Synonym(s):

CD49d

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Integrin α4 Antibody, clone P4G9, ascites fluid, clone P4G9, Chemicon®

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

P4G9, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG2bκ

NCBI accession no.

NM_000885.4

UniProt accession no.

P13612

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGA4(3676)

Preparation Note

Store at -20 °C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone P4G9 validated for use in IH.
Immunocytochemistry on Jurkat cells at 1:1,600.

Inhibits attachment of hematopoeitic cells and fibroblasts to fibronectin (note: sodium azide should be removed prior to attachment assay).

Optimal working dilutions must be determined by the end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Biochem/physiol Actions

Human integrin alpha4. The alpha4beta1 integrin receptor recognizes an RGD-independent alternative adhesion site in the CS-1 region of fibronectin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Other Notes

Replaces: 04-1131

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Fabienne De Toni-Costes et al.
PloS one, 5(3), e9807-e9807 (2010-03-31)
Cell survival mediated by integrin engagement has been implicated in cell adhesion-mediated drug resistance. We have recently demonstrated that the activation of glycogen synthase kinase 3 beta (GSK3beta) is a new pathway supporting the chemoresistance of leukemic cells adhered to
Barbara Garmy-Susini et al.
The Journal of clinical investigation, 115(6), 1542-1551 (2005-05-20)
Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that
Ming-Yi Lee et al.
PloS one, 4(10), e6913-e6913 (2009-10-23)
Human placental multipotent mesenchymal stromal cells (hPMSCs) can be isolated from term placenta, but their angiogenic ability and the regulatory pathways involved are not known. hPMSCs were shown to express integrins alpha(v), alpha(4), alpha(5), beta(1), beta(3), and beta(5) and could

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