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Merck
CN

MAB1581

Anti-Aggrecan Antibody

CHEMICON®, mouse monoclonal, Cat-315

Synonym(s):

CSPG

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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Product Name

Anti-Chondroitin Sulfate Proteoglycan Antibody, Core Protein Epitope, clone Cat-315, ascites fluid, clone Cat-315, Chemicon®

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

Cat-315, monoclonal

species reactivity

feline, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgM

UniProt accession no.

P16112

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ACAN(176)

Biochem/physiol Actions

Chondroitin sulfate proteoglycan (CSPG), protein core epitope

Application

This Anti-Chondroitin Sulfate Proteoglycan Antibody, Core Protein Epitope, clone Cat-315 is validated for use in IP, WB, IC, IH for the detection of Chondroitin Sulfate Proteoglycan.
Immunohistochemistry: 1:2,000 on 4% paraformaldehyde fixed frozen tissue.

Immunocytochemistry: 1:500 on primary cultures of neurons.

Immunoblot: 1:5,000 recognizes a band at 680 kDa.

Immunoprecipitation.

Optimal working dilutions must be determined by the end user.

Immunogen

Epitope: Core Protein Epitope

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrew Nathaniel Stewart et al.
Restorative neurology and neuroscience, 35(4), 395-411 (2017-06-10)
Utilizing genetic overexpression of trophic molecules in cell populations has been a promising strategy to develop cell replacement therapies for spinal cord injury (SCI). Over-expressing the chemokine, stromal derived factor-1 (SDF-1α), which has chemotactic effects on many cells of the
Paulette A McRae et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(20), 5405-5413 (2007-05-18)
An important role for the neural extracellular matrix in modulating cortical activity-dependent synaptic plasticity has been established by a number of recent studies. However, identification of the critical molecular components of the neural matrix that mediate these processes is far
Claudia Loebel et al.
Advanced functional materials, 30(44) (2021-07-03)
Hydrogels are engineered with biochemical and biophysical signals to recreate aspects of the native microenvironment and to control cellular functions such as differentiation and matrix deposition. This deposited matrix accumulates within the pericellular space and likely affects the interactions between
Alicia L Hawthorne et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(2), 420-430 (2010-01-15)
Embryonic CNS neurons can migrate from the ventricular zone to their final destination by radial glial-guided locomotion. Another less appreciated mechanism is somal translocation, where the young neuron maintains its primitive ventricular and pial processes, through which the cell body
Shinji Miyata et al.
Frontiers in integrative neuroscience, 12, 3-3 (2018-02-20)
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain development. Emerging evidence indicates that PNNs promote the maturation of PV cells
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