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LCGL04TP6

Millipore

Charged Durapore® 0.22 µm, Optiseal® Cartridge

OptiSeal® 4 in., matrix Charged Durapore®

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Synonym(s):
Optiseal Charged Durapore Cartridge Filter 0.22 m
UNSPSC Code:
23151806
eCl@ss:
32031690

material

PVDF
polypropylene
polypropylene support
silicone seal

Quality Level

400

sterility

non-sterile

Sterilization Compatibility

autoclavable compatible
steam-in-place compatible

product line

OptiSeal® 4 in.

feature

hydrophilic

manufacturer/tradename

OptiSeal®

parameter

≤4 mL/min air diffusion at 2.1 bar (30 psig) and 23 °C (in water)
0.35 bar max. differential pressure (5 psid) at 121 °C (Forward)
0.35 bar max. inlet pressure (5 psi) at 121 °C (Forward)
15 L/min flow rate at 850 mbar (ΔP)
3.5 bar max. differential pressure (50 psid) at 25 °C (Reverse)
3.5 bar max. differential pressure (50 psid) at 80 °C (Forward)
3.5 bar max. inlet pressure (50 psi) at 25 °C (Reverse)
3.5 bar max. inlet pressure (50 psi) at 80 °C (Forward)
5.5 bar max. differential pressure (80 psid) at 25 °C (Forward)
5.5 bar max. inlet pressure (80 psi) at 25 °C (Forward)

technique(s)

sterile filtration: suitable

L

4 in.

cartridge nominal length

4 in. (10 cm)

filtration area

0.2 m2

impurities

≤0.5 EU/mL bacterial endotoxins (LAL test, Aqueous extraction)
<0.5 EU/mL USP bacterial endotoxins (LAL test, sample aqueous extraction)

gravimetric extractables

≤10 mg/cartridge

matrix

Charged Durapore®

pore size

0.22 μm

input

sample type liquid

bubble point

≥2760 mbar (40 psig), air with water at 23 °C

cartridge code

not applicable

Related Categories

General description

Device Configuration: Cartridge

Packaging

Double Easy-Open bag

Other Notes

These products are manufactured in a facility which adheres to FDA Good Manufacturing Practices.
Directions for Use

  • Organism Retention: Microorganism
  • Mode of Action: Filtration (size exclusion)
  • Application: BioProcessing
  • Intended Use: Reduction or removal of microorganism/bioburden
  • Instructions for Use: Please refer Wetting Instructions for Filter Units with Durapore® Membrane user guide
  • Storage Statement: Store in dry location
  • Disposal Statement: Dispose of in accordance with applicable federal, state and local regulations.

Preparation Note

Sterilization Method
10 SIP cycles of 30 min @ 135 °C
This product was manufactured with a Durapore® membrane which meets the criteria for a "non-fiber releasing" filter as defined in 21 CFR 210.3 (b) (6).

Analysis Note

Bacterial Retention
Samples were quantitatively retentive of a minimum Brevundimonas diminuta challenge concentration of 1 x 10⁷ CFU/cm² using ASTM® F838 methodology.
Gravimetric Extractables: after 24 hours in water at controlled room temperature
Will meet the USP Oxidizable Substances Test requirements after a water flush of ≥500 mL

Legal Information

ASTM is a registered trademark of American Society for Testing and Materials
Durapore is a registered trademark of Merck KGaA, Darmstadt, Germany
OPTISEAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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