HCCBP1MAG-58K
MILLIPLEX® Human Circulating Cancer Biomarker Magnetic Bead Panel - Cancer Multiplex Assay
Circulating Cancer Biomarker Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple oncology biomarkers in various tumor types in human serum, plasma and cell culture samples.
Synonym(s):
human cancer biomarker immunoassay panel, luminex human circulating cancer biomarkers multiplex assay, millipore human circulating cancer biomarkers multiplex kit
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Quality Level
species reactivity
human
manufacturer/tradename
Milliplex®
assay range
accuracy: 35-108%
standard curve range: 0.09-67 mU/mL
(β-HCG)
standard curve range: 0.7-500 pg/mL
(IL-6)
standard curve range: 1.3-1000 pg/mL
(IL-8, TNFα)
standard curve range: 2.7-2000 pg/mL
(TRAIL, TGF-α)
standard curve range: 6.9-5000 pg/mL
(SCF)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
Related Categories
General description
Circulating cancer biomarkers give insight beyond intracellular oncogenesis and into how the body responds to the presence of a tumor, the dysregulation of homeostasis, and the relationship between a tumor and its environment. Multianalyte panels have become essential tools that enable researchers to measure cancer biomarkers simultaneously, teasing out these relationships and applying them to understand tumor biology.
MILLIPLEX® Circulating Cancer Biomarker Panel 1 is a 25-plex kit that can be used for the simultaneous quantification of any or all of the following analytes in serum, plasma and tissue/cell lysate and culture supernatant samples: AFP, CA125, CA15-3, CA19-9, CEA, CYFRA21-1, sFas, sFasL, FGF2, β-HCG, HE4, HGF, IL-6, IL-8, Leptin, MIF, Osteopontin, Prolactin, PSA (free), PSA (total), SCF, TGFα, TNFα, TRAIL and VEGF. Note that certain biomarkers are tumor specific, such as PSA, while others, such as IL-8, have been detected in many cancers. PSA (free) and PSA (total) cannot be plexed together. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Circulating Cancer
MILLIPLEX® Circulating Cancer Biomarker Panel 1 is a 25-plex kit that can be used for the simultaneous quantification of any or all of the following analytes in serum, plasma and tissue/cell lysate and culture supernatant samples: AFP, CA125, CA15-3, CA19-9, CEA, CYFRA21-1, sFas, sFasL, FGF2, β-HCG, HE4, HGF, IL-6, IL-8, Leptin, MIF, Osteopontin, Prolactin, PSA (free), PSA (total), SCF, TGFα, TNFα, TRAIL and VEGF. Note that certain biomarkers are tumor specific, such as PSA, while others, such as IL-8, have been detected in many cancers. PSA (free) and PSA (total) cannot be plexed together. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Circulating Cancer
Specificity
Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Application
- Analytes: α-Fetoprotein (AFP), CA125, CA15-3, CA19-9, CEA, CYFRA21-1, sFas (TNFRSF6), sFasL, FGF-2 (FGF-basic), β-HCG (HCGβ), HE4, HGF, IL-6, IL-8 (CXCL8), Leptin, MIF, Osteopontin (OPN), Prolactin, PSA (free)*, PSA (total)*, SCF, TGFα, TNFα, TRAIL (TNFSF10), VEGF.
- Note: Total PSA and Free PSA cannot be plexed together
- Recommended Sample Type: Human serum, plasma or tissue/cell culture supernatants or lysates
- Recommended Sample Dilution: 25 μL per well of 1:6 diluted plasma or serum, or 25 μL cell culture psaesaa sample undiluted or diluted in appropriate control medium
- Assay Run Time: Overnight (16-18 hr) at 2-8°C
- Research Category: Cancer
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Packaging
Everything you need in a single kit.
Components
Human Circulating Cancer Biomarker Panel 1 Standard (HCC-8058)
Human Circulating Cancer Biomarker Panel 1 Quality Controls 1 and 2 (HCC-6058)
Serum Matrix (HCP-SM)
Note: Contains 0.08% Sodium Azide
Set of one 96-Well Plate with 2 Sealers (MAG-PLATE)
Assay Buffer (L-AB)
Note: Contains 0.08% Sodium Azide
10X Wash Buffer (L-WB)
Note: Contains 0.05% Proclin
Human Circulating Cancer Biomarker Panel 1 Detection Antibodies (HCC-1058 or HCC-1058-2)
Streptavidin-Phycoerythrin (L-SAPE 4)
Bead Diluent (LBD-4)
Human Circulating Cancer Biomarker Panel 1 Quality Controls 1 and 2 (HCC-6058)
Serum Matrix (HCP-SM)
Note: Contains 0.08% Sodium Azide
Set of one 96-Well Plate with 2 Sealers (MAG-PLATE)
Assay Buffer (L-AB)
Note: Contains 0.08% Sodium Azide
10X Wash Buffer (L-WB)
Note: Contains 0.05% Proclin
Human Circulating Cancer Biomarker Panel 1 Detection Antibodies (HCC-1058 or HCC-1058-2)
Streptavidin-Phycoerythrin (L-SAPE 4)
Bead Diluent (LBD-4)
Storage and Stability
Recommended storage for kit components is 2 - 8°C.
Other Notes
Please note: Total PSA and Free PSA cannot be plexed together.
Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Target Organs
Respiratory Tract
Storage Class Code
10 - Combustible liquids
Regulatory Information
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Certificates of Analysis (COA)
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Jonathan A Kluge et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(21), 5892-5897 (2016-05-11)
Advanced personalized medical diagnostics depend on the availability of high-quality biological samples. These are typically biofluids, such as blood, saliva, or urine; and their collection and storage is critical to obtain reliable results. Without proper temperature regulation, protein biomarkers in
Sandra Tuyaerts et al.
Frontiers in nutrition, 5, 138-138 (2019-01-29)
Curcumin is a botanical with anti-tumor and immunomodulatory properties. We hypothesized that curcumin supplementation might influence inflammatory biomarker levels in endometrial carcinoma (EC). In this open-label, non-randomized phase 2 study (NCT02017353), seven EC patients consumed 2 g/day Curcumin Phytosome (CP)
Effect of different exercise modalities plus a hypocaloric diet on inflammation markers in overweight patients: a randomised trial.
Loria-Kohen, V; Fernandez-Fernandez, C; Bermejo, LM; Morencos, E; Romero-Moraleda et al.
Clinical Nutrition (Edinburgh, Scotland) null
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Pils, D; Tong, D; Hager, G; Obermayr, E; Aust, S; Heinze, G; Kohl, M; Schuster, E; Wolf et al.
BMC Cancer null
Chen-Tzu Chiu et al.
Cancers, 12(6) (2020-06-18)
Head and neck cancer (HNC) accounts for more than 330,000 cancer deaths annually worldwide. Despite late diagnosis being a major factor contributing to HNC mortality, no satisfactory biomarkers exist for early disease detection. Cytoplasmic gelsolin (cGSN) was discovered to predict
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