GF442
HumanKine® TNF alpha, Human Recombinant Xeno-Free
Synonym(s):
Tumor Necrosis Factor-α, TNFa
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About This Item
UNSPSC Code:
12352200
eCl@ss:
32160405
Recommended Products
Assay
>95% (SDS-PAGE)
manufacturer/tradename
HumanKine®
impurities
<0.1 μg/mg protein endotoxin (<1 EU/μg)
UniProt accession no.
shipped in
dry ice
General description
Tumor necrosis factor alpha (TNF-α), is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.
Quality
Bioactivity assay: Determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of
Actinomycin D. Typically <0.9 ng/mL ED50.
Actinomycin D. Typically <0.9 ng/mL ED50.
Physical form
HumanKine TNF alpha is manufactured using all non-animal reagents and is considered Xeno-Free
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Certificates of Analysis (COA)
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Peng Sun et al.
The Journal of pharmacology and experimental therapeutics, 382(3), 266-276 (2022-07-03)
Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is implicated in disease progression. We recently described the discovery
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