Skip to Content
Merck
CN

FCABS400F

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC

Milli-Mark®, from rabbit

Synonym(s):

Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC, Milli-Mark®, from rabbit

biological source

rabbit

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG

NCBI accession no.

NP_004097

UniProt accession no.

P30273

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FCER1G(2207)

Related Categories

Physical form

Protein A purified
Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Analysis Note

Control
RBL cells
Evaluated by flow cytometry using RBL cells.

Application

Milli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.
Research Category
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms

Biochem/physiol Actions

Recognizes and is specific for FcεRI, γ-subunit.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

10 kDa Calculated
Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

Immunogen

Synthetic peptide corresponding to amino acids 80-86 of γ-subunit of Fc receptors.

Other Notes

Optimal working dilutions must be determined by end user for other instruments
Unconjugated antibody (Cat No. 06-727) has been shown to work on Human and Mouse.

Preparation Note

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Zeguang Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 207(10), 2534-2544 (2021-10-10)
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with
James D Dahlvang et al.
Journal of immunology (Baltimore, Md. : 1950), 210(8), 1108-1122 (2023-03-08)
CMV infection alters NK cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK cells, typically express CD57 and NKG2C but lack expression of the FcRγ-chain (gene: FCER1G, FcRγ), PLZF, and SYK. Functionally, adaptive NK
Cristina Capuano et al.
Frontiers in immunology, 9, 1031-1031 (2018-06-06)
Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as
Ralf Grutza et al.
Journal of immunology (Baltimore, Md. : 1950), 204(11), 2910-2917 (2020-04-15)
Infection with the human CMV associates with phenotypic alterations in lymphocyte subsets. A highly reproducible finding in CMV-seropositive individuals is an expansion of NKG2Cpos NK cells. In this study, we analyzed if the altered NK cell compartment in CMV-seropositive human
Carmen Gómez-Escolar et al.
EMBO reports, 23(12), e55000-e55000 (2022-10-08)
Germinal centers (GC) are microstructures where B cells that have been activated by antigen can improve the affinity of their B cell receptors and differentiate into memory B cells (MBCs) or antibody-secreting plasma cells. Here, we have addressed the role
View All Related Papers

Articles

Flow Cytometry Troubleshooting Guide

Troubleshooting guide offers solutions for common flow cytometry problems, ensuring improved analysis performance.

Flow Cytometry Dye Selection Tips

Flow cytometry dye selection tips match fluorophores to flow cytometer configurations, enhancing panel performance.

Protocols

Flow Cytometry Guide

Explore our flow cytometry guide to uncover flow cytometry basics, traditional flow cytometer components, key flow cytometry protocol steps, and proper controls.

Key Steps in Flow Cytometry Protocols

Learn key steps in flow cytometry protocols to make your next flow cytometry experiment run with ease.

流式细胞分析实验方案主要步骤

了解流式细胞分析实验方案的主要步骤，以便轻松完成后续流式细胞分析实验。

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service