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EQCYTMG-93KPX23

MILLIPLEX® Equine Cytokine/Chemokine Panel

Premixed Equine Cyokine/Chemokine 23-Plex Panel

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UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

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Product Name

MILLIPLEX® Equine Cytokine/Chemokine Panel, Premixed Equine Cyokine/Chemokine 23-Plex Panel

species reactivity

horse

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 76%
(IL-6)
accuracy: 78%
(FGF-2)
accuracy: 82%
(G-CSF)
accuracy: 85%
(IL-13)
accuracy: 87%
(TNFα)
accuracy: 88%
(RANTES/CCL5)
accuracy: 90%
(IL-2)
accuracy: 92%
(GM-CSF)
accuracy: 94%
(IL-18)
accuracy: 97%
(GRO)
sensitivity: 1.4 pg/mL
(IL-6)
sensitivity: 10.6 pg/mL
(IL-5)
sensitivity: 13.5 pg/mL
(IL-2)
sensitivity: 15.4 pg/mL
(IL-17A)
sensitivity: 16.3 pg/mL
(FGF-2)
sensitivity: 16.7 pg/mL
(IP-10)
sensitivity: 165 pg/mL
(IFNγ)
sensitivity: 25.3 pg/mL
(IL-18)
sensitivity: 29.3 pg/mL
(IL-1β)
sensitivity: 3.9 pg/mL
(RANTES/CCL5)
sensitivity: 3.94 pg/mL
(GM-CSF)
sensitivity: 340 pg/mL
(G-CSF)
sensitivity: 355 pg/mL
(IL-4)
sensitivity: 39-130 pg/mL
(IL-13)
sensitivity: 39.1 pg/mL
(IL-1α)
sensitivity: 399 ng/mL
(MCP-1)
sensitivity: 457 pg/mL
(Fractalkine/CS3CL1)
sensitivity: 49.2 pg/mL
(IL-12 (p70))
sensitivity: 5.2 pg/mL
(TNFα)
sensitivity: 62.5 pg/mL
(IL-10)
sensitivity: 7.8 pg/mL
(GRO)
sensitivity: 74.3 pg/mL
(IL-8/CXCL8)
sensitivity: 8.3 pg/mL
(Eotaxin/CCL11)
standard curve range: 15-15,000 pg/mL
(IL-17A)
standard curve range: 15-15,000 pg/mL
(IL-2)
standard curve range: 15-15,000 pg/mL
(IL-5)
standard curve range: 15-15,000 pg/mL
(IL-6)
standard curve range: 15-15,000 pg/mL
(IP-10)
standard curve range: 24-25,000 pg/mL
(FGF-2)
standard curve range: 29-30,000 pg/mL
(IL-1β)
standard curve range: 293-300,000 pg/mL
(IL-4)
standard curve range: 34-35,000 pg/mL
(IL-18)
standard curve range: 342-350,000 ng/mL
(MCP-1)
standard curve range: 39-40,000 pg/mL
(IL-12 (p70))
standard curve range: 39-40,000 pg/mL
(IL-13)
standard curve range: 4-4,000 pg/mL
(TNFα)
standard curve range: 488-500,000 pg/mL
(IFNγ)
standard curve range: 49-50,000 pg/mL
(IL-10)
standard curve range: 5-5,000 pg/mL
(GM-CSF)
standard curve range: 5-5,000 pg/mL
(RANTES/CCL5)
standard curve range: 586-600,000 pg/mL
(Fractalkine/CS3CL1)
standard curve range: 59-60,000 pg/mL
(IL-1α)
standard curve range: 59-60,000 pg/mL
(IL-8/CXCL8)
standard curve range: 6-6,000 pg/mL
(GRO)
standard curve range: 7-7,000 pg/mL
(Eotaxin/CCL11)
standard curve range: 78-80,000 pg/mL
(G-CSF)

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

Inflammation and immune cell response are key to maintaining homeostasis. The more we understand the mechanisms of disease, the more we discover the role that inflammation plays in the etiology of disease. This is as true for horses as it is for humans. Both experience immunological diseases, such as infectious diseases, osteoarthritis, and respiratory diseases, as well as neurologic, metabolic, and cardiovascular diseases and cancer. Until now the ability to measure levels of cytokines and chemokine in horses had been limited primarily to ELISAs. Researchers can now measure multiple inflammation biomarkers simultaneously using the MILLIPLEX® Equine Cytokine/Chemokine Panel, based on the Luminex® xMAP® technology.

MILLIPLEX® Equine Cytokine/Chemokine Premix Panel is a 23-plex kit used for the simultaneous quantification of all the following analytes in equine serum, plasma, or culture supernatant samples: Eotaxin/CCL11, FGF-2, Fractalkine/CS3CL1, G-CSF, GM-CSF, GRO, IFN, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8/CXCL8, IL-10, IL-12 (p70), IL-13, IL-17a, IL-18, IP-10, MCP-1, RANTES/CCL5 and TNFα. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines
Researching horse cytokines and chemokines is pivotal for advancing our understanding of equine immunology and the underlying mechanisms of various diseases. By investigating the roles and interactions of these signaling molecules, scientists can uncover critical insights into inflammatory processes, immune responses, and the pathophysiology of equine conditions. This knowledge not only enhances our fundamental understanding of equine biology but also drives the development of targeted therapeutic strategies and interventions in equine medicine.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 23 analytes in equine serum, plasma, and cell culture supernatants.Analytes included: Eotaxin/CCL11, FGF-2, Fractalkine/CX3CL1, G-CSF, GM-CSF, GRO/KC, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 (p70), IL-13, IL-17A, IL-18, IP-10 (CXCL10), MCP-1, RANTES (CCL5), TNF-αAssay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Bulk Packaging Options Available: Our kits can be purchased in bulk packaging, ideal for high-throughput laboratories, allowing for greater flexibility in inventory management.
  • Comparative Immunology Studies: Leverage equine models to explore immune responses that are relevant to both veterinary and human health, enhancing the understanding of shared inflammatory pathways and therapeutic approaches.
  • User-Friendly Protocols: Easy-to-follow instructions make it simple to integrate into your laboratory workflow.
  • Enhanced Research Capabilities: Support your equine research with detailed cytokine profiles, helping you uncover the mechanisms behind health and disease.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

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Hannah C Valigura et al.
Journal of animal science, 99(8) (2021-06-29)
Mitigation of exercise-induced stress is of key interest in determining ways to optimize performance horse health. To test the hypothesis that dietary supplementation of a Saccharomyces cerevisiae fermentation product would decrease markers of exercise-induced stress and inflammation in young horses

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