ECMatrix-511 Silk E8 Laminin Substrate

Human pluripotent stem cells (ES and iPS cells) express α6β1 as the major integrin species and therefore can be maintained stably and expanded efficiently in feeder-free conditions on culture vessels coated with it′s binding partner laminin-511. However, laminin-511 is not suitable for large-scale production because of its large molecular weight and heterotrimeric nature. Professor Kiyotoshi Sekiguchi′s group (Matrixome, Inc.) have solved this problem by producing a recombinant E8 fragment of laminin-511 at large-scale while retaining the full integrin binding activity. The ECMatrix-511 E8 Laminin Substrate can be used to culture pluripotent stem cells in feeder-free conditions with numerous added benefits over traditional methods.

ECMatrix-511 E8 Laminin Substrates should be stored at 2-8°C. Avoid multiple freeze-thaw cycles and protect from light.

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