CBL52
Anti-Insulin-like Growth Factor-I Antibody, clone M23
clone M23, Chemicon®, from mouse
Synonym(s):
IGF-I
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-Insulin-like Growth Factor-I Antibody, clone M23, clone M23, Chemicon®, from mouse
biological source
mouse
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
M23, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... IGF1(3479)
Application
Immunohistological staining of tissue sections on frozen or formalin fixed paraffin wax embedded sections
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
This Anti-Insulin-like Growth Factor-I Antibody, clone M23 is validated for use in IH(P) for the detection of Insulin-like Growth Factor-I.
Biochem/physiol Actions
The basic IGF-1-like forms (pl>9.0) showed substantial cross-reactivity, as did rat and mouse sera. Monoclonal antibody BM23 was capable of abolishing the biological activities of IGF-1 in vitro bioassays for insulin-like, mitogenic and sulphation activities.
AFFINITY CONSTANT: The affinity of monoclonal antibody BM23 for IGF-1 was 1 x 10E10 L/mole and the cross reactivities of IGF-2, MSA and porcine insulin were 1%, 0.05% and 0.0001% respectively
AFFINITY CONSTANT: The affinity of monoclonal antibody BM23 for IGF-1 was 1 x 10E10 L/mole and the cross reactivities of IGF-2, MSA and porcine insulin were 1%, 0.05% and 0.0001% respectively
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Purified human IGF-1.
Physical form
Format: Purified
The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Preparation Note
For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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An immunoenzymatic method to measure IGF-1 in milk.
A Guidi, L Castigliego, G Iannone, A Armani, D Gianfaldoni
Veterinary Research Communications null
E Maiorano et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(2), 110-119 (2000-08-11)
Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels
Ali Aslan et al.
Medical science monitor : international medical journal of experimental and clinical research, 25, 5510-5517 (2019-07-26)
BACKGROUND There is no study in the literature investigating the expression levels of WT1, p53, and IGF-1 in colon polyp subtypes. In this study, we aimed to investigate the expression levels of IGF-1, p53, and WT1 in colon polyp subtypes
Hakryul Jo et al.
Molecular and cellular biology, 28(13), 4285-4299 (2008-05-07)
Cancer cells in their respective microenvironments must endure various growth-constraining stresses. Under these conditions, the cancer cell-derived factors are thought to modulate the signaling pathways between cell growth and dormancy. Here, we describe a cancer cell-derived regulatory system that modulates
Y-F Huang et al.
British journal of cancer, 99(7), 1096-1102 (2008-09-11)
This study was aimed to identify the expression and the correlation of insulin-like growth factor-1 (IGF-1) system and their prognostic impacts in cervical cancer. Seventy-two patients with early-stage cervical cancer were eligible. We obtained the serum levels of total IGF-1
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