CBL1360
Anti-CD117 Antibody, clone ACK2
clone ACK2, Chemicon®, from rat
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Synonym(s):
c-kit, SCF Receptor
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rat
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
ACK2, monoclonal
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
input
sample type hematopoietic stem cell(s)
sample type mesenchymal stem cell(s)
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... KIT(3815)
Related Categories
General description
This 145 kDa molecule is a member of the tyrosine kinase receptor family and is expressed by a majority of hematopoietic progenitor cells. The interaction of the mouse c-kit receptor and steel factor promotes proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells, and plays a role in signaling and activation of these cells.
Specificity
Specifically recognizes mouse CD117, known as c-kit receptor, stem cell factor receptor and steel factor receptor.
Application
Detect CD117 using this Anti-CD117 Antibody, clone ACK2 validated for use in FC, IH, IP, FUNC & WB.
Flow Cytometry: 0.2 μg per 10e6 cells
Immunoprecipitation
Immunohistochemistry (Frozen)
Western blot
Blocking Ligand Binding
Optimal working dilutions must be determined by the end user.
Immunoprecipitation
Immunohistochemistry (Frozen)
Western blot
Blocking Ligand Binding
Optimal working dilutions must be determined by the end user.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Hematopoietic Stem Cells
Mesenchymal Stem Cells
Hematopoietic Stem Cells
Mesenchymal Stem Cells
Target description
145 kDa
Linkage
Replaces: CBL1360P
Physical form
Format: Purified
Protein A purified
The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide.
Storage and Stability
For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Analysis Note
Control
Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells
Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cheng-Hai Zhang et al.
Nature communications, 7, 11358-11358 (2016-04-23)
Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we
L Sha et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3840-3849 (2010-06-15)
Gastric and small intestinal circular smooth muscle layers have a transwall resting membrane potential (RMP) gradient that is dependent on release of carbon monoxide (CO) from interstitial cells of Cajal (ICCs). Our aim was to determine whether a RMP gradient
Yao Fei Hu et al.
Stem cells (Dayton, Ohio), 24(12), 2692-2702 (2006-08-26)
Here, we report the first transcriptome for mouse epidermal neural crest stem cells (EPI-NCSC, formerly eNCSCs). In addition, our study resolves conflicting opinions in the literature by showing that EPI-NCSC are distinct from other types of skin-resident stem cells/progenitors. Finally
Jumpei Kondo et al.
The Journal of pathology, 252(4), 441-450 (2020-09-19)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gut. GISTs are thought to arise solely from interstitial cells of Cajal (ICC), a KIT-positive population that controls gut motility. Activating gain-of-function mutations in KIT and PDGFRA are
Jumpei Kondo et al.
Gastroenterology, 149(2), 407-419 (2015-04-30)
Interstitial cells of Cajal (ICC) control intestinal smooth muscle contraction to regulate gut motility. ICC within the plane of the myenteric plexus (ICC-MY) arise from KIT-positive progenitor cells during mouse embryogenesis. However, little is known about the ontogeny of ICC
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