CBL1348
Anti-Integrin beta1 Antibody, clone HM beta 1.1
clone HM beta 1.1, from hamster
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Synonym(s):
CD29 antigen, Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, fibronectin receptor beta subunit, integrin VLA-4 beta subunit, integrin beta 1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen
CD29 includes MDF2,
CD29 includes MDF2,
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
hamster
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
HM beta 1.1, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGB1(3688)
mouse ... Itgb1(16412)
General description
Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.
Specificity
Other species have not been tested.
Immunogen
Epitope: Full length
Purified mouse VLA-4 antigen
Application
Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Quality
Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.
Target description
130 kDa
Physical form
Format: Purified
Protein G Purified
Purified in PBS with 0.05% NaN3.
Storage and Stability
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Analysis Note
Control
NIH3T3, A431
NIH3T3, A431
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Fahmy A Mamuya et al.
American journal of physiology. Renal physiology, 313(4), F1026-F1037 (2017-07-14)
The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion
Helena P Felgueiras et al.
Langmuir : the ACS journal of surfaces and colloids, 30(31), 9477-9483 (2014-07-24)
Functionalization of surfaces with poly(sodium styrenesulfonate) (poly(NaSS)) has recently been found to enhance osteointegration of implantable materials. Radical polymerization of poly(NaSS) on titanium (Ti)-based substrates has been used to improve their long-term performance by preventing fibrosis and consequently implant loosening.
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