ABT157
Anti-Syndecan-4 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
SYND4, Amphiglycan, Ryudocan core protein
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
species reactivity (predicted by homology)
chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SDC4(6385)
General description
Syndecan-4 (Amphiglycan; Ryudocan core protein) is one of four members of the syndecan proteoglycan family. The syndecan proteins bind heparan sulfate and mediate the signaling of growth factors, such as fibroblast growth factor, that recognize and bind heparan chains. Unlike other members of this family, syndecan-4 is ubiquitously expressed, and is targeted to focal adhesions, possibly by a PKC-mediated pathway. Previous studies have reported an increase in focal adhesions in cells overexpressing syndecan-4. This protein also plays an important role in wound healing, by modulating the signaling of Rho-GTPases Rac1, RhoG, and RhoA.
Specificity
This antibody recognizes the cytoplasmic domain of Syndecan-4
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Syndecan-4.
Application
Immunohistochemistry Analysis: A 1:100-1,000 dilution from a representative lot detected Syndecan-4 in human lung carcinoma and in distal tubules of normal human kidney tissue.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
This Anti-Syndecan-4 Antibody is validated for use in Western Blotting, IHC(P) for the detection of Syndecan-4.
Quality
Evaluated by Western Blot in HEP2 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Syndecan-4 in 10 µg of HEP2 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Syndecan-4 in 10 µg of HEP2 cell lysate.
Target description
~80/32 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HEP2 cell lysate
HEP2 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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