ABS446
Anti-GPVI Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
GPVI Antibody, Glycoprotein VI, GPIV, Platelet glycoprotein VI precursor, GP6, Glycoprotein 6
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GP6(51206)
General description
Glycoprotein 6 (GP6), or glycoprotein VI (GPVI), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GP6 is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GP6 is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GP6 is expressed in megakaryocytes and platelets. The signaling pathway of GP6 involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GP6.
Specificity
This antibody recognizes the C-terminus of GPVI.
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human GPVI.
Application
Anti-GPVI Antibody is a highly specific rabbit polyclonal antibody, that targets Glycoprotein 6 & has been tested in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected GPVI in human heart tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells.
Quality
Evaluated by Western Blotting/Peptide Inhibition Assay in A20 cell lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate.
Target description
~115 kDa observed. Uniprot describes 3 isoforms at ~35 kDa, ~37 kDa, and ~67 kDa
Linkage
Replaces: MABT473
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Biswajit Saha et al.
Science advances, 7(30) (2021-07-23)
Platelets extravasate from the circulation into tumor microenvironment, enable metastasis, and confer resistance to chemotherapy in several cancers. Therefore, arresting tumor-platelet cross-talk with effective and atoxic antiplatelet agents in combination with anticancer drugs may serve as an effective cancer treatment
Benjamin E J Spurgeon et al.
Current protocols, 1(5), e112-e112 (2021-05-06)
Platelets are small blood cells that contribute to hemostasis, immunity, and inflammation. Characterization of platelet surface markers allows for differentiation of activated platelets from resting platelets, diagnosis of platelet disorders, and investigation of platelet biology and pathology. In this article
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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