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Key Documents

ABS236

Sigma-Aldrich

Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526

from rabbit, purified by affinity chromatography

Synonym(s):

Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc)

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1 EA
CN¥6,148.65

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Available to ship onApril 27, 2025Details

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CN¥6,148.65

Available to ship onApril 27, 2025Details

Sign In for Best Price
Request a Bulk Order

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_058982

UniProt accession no.

P14137

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Ascentis® C18 HPLC Column 3 μm particle size, L × I.D. 10 cm × 4.6 mm

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Ascentis® C18 HPLC Column 3 μm particle size, L × I.D. 10 cm × 2.1 mm

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Ascentis® C18 HPLC Column

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix

fully porous particle, silica gel high purity, spherical

matrix

fully porous particle, silica gel high purity, spherical

matrix

fully porous particle, silica gel high purity, spherical

matrix

fully porous particle, silica gel high purity, spherical

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

product line

Ascentis®

product line

Ascentis®

product line

Ascentis®

product line

Ascentis®

pore size

100 Å

pore size

100 Å

pore size

100 Å

pore size

100 Å

General description

As a member of the cytochrome P450 family, Cytochrome P450 Side Chain Cleavage Enzyme (scc) catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone during the first step of steroid biosynthesis. It is expressed in certain organs, such as ovaries, adrenal glands, and testis. Deficiency in CYP11A1 is commonly associated with adrenal insufficiency, and with variable degrees of disorder of sex development (DSD).

Specificity

This antibody recognizes the C-terminus of Cytochrome P450 (scc), a.a. 509-526.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of rat Cytochrome P450 (scc), a.a. 509-526.

Application

Immunohistochemistry Analysis: A 1:4,000-8,000 dilution from a representative lot detected Cytochrome P450 (scc) in rat adrenal gland and rat testis tissue.
This Cytochrome P450 (scc) antibody is validated for use in WB & IHC for the detection of the Cytochrome P450 (scc) protein.

Quality

Evaluated by Western Blot in rat adrenal tissue lysate.

Western Blot Analysis: 0.02 µg/mL of this antibody detected Cytochrome P450 (scc) in 10 µg of rat adrenal tissue lysate.

Target description

~52 kDa observed. On higher percentage gels and longer exposures, 8 kDa cleavage product can be detected.

Linkage

Replaces: AB1294

Analysis Note

Control
Rat adrenal tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

    • Certificates of Analysis (COA)

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    Li Guang-Yu et al.
    Molecular reproduction and development, 83(3), 226-235 (2016-03-21)
    Myeloid cell leukemia-1 (MCL1), an anti-apoptotic member of the BCL2 family, is expressed abundantly in the testis. Previous characterization revealed that MCL1 is expressed exclusively in the Leydig cells in the mouse testis, yet what it does in these cells
    A Berthon et al.
    Human molecular genetics, 26(18), 3495-3507 (2017-09-16)
    Inactivating mutations in the Armadillo repeat-containing 5 (ARMC5) gene have recently been discovered in primary macronodular adrenal hyperplasia (PMAH), a cause of Cushing syndrome. Biallelic ARMC5 inactivation in PMAH suggested that ARMC5 may have tumor suppressor functions in the adrenal
    Sheu-Ran Choi et al.
    Frontiers in pharmacology, 10, 1439-1439 (2019-12-24)
    Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the neurosteroidogenic enzyme, cytochrome P450 side-chain cleavage enzyme (P450scc), is the initiating enzyme of steroidogenesis, P450scc has not been

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