Skip to Content
Merck
CN
All Photos(1)

Key Documents

Safety Information

ABS2120

Sigma-Aldrich

Anti-methylglutaryl-lysine

from rabbit

Synonym(s):

3-methylglutaryl (MG)-lysine, MG

Sign Into View Organizational & Contract Pricing

Select a Size

200 μG
CN¥6,248.20

CN¥6,248.20

Please contact Customer Service for Availability
New, lower price on this item!
Sign In for Best Price
Request a Bulk Order
All Photos(1)

Select a Size

Change View
200 μG
CN¥6,248.20

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CN¥6,248.20

Please contact Customer Service for Availability
New, lower price on this item!
Sign In for Best Price
Request a Bulk Order

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

all

packaging

antibody small pack of 25 μg

technique(s)

western blot: suitable

isotype

IgG

target post-translational modification

unmodified

General description

Acetylation of lysine residues is proteins has emerged as an important mechanism in regulation and coordination of normal and pathophysiological cell metabolism. Lysine 3-methylglutaryl is a newer post-translational protein modification that occurs under normal basal conditions. In murine models of HMG-CoA lyase deficiency, higher levels of protein lysine 3-MGylation are observed. This rabbit polyclonal antibody specifically detects chemically modified proteins containing 3-methylglutaryl lysine modifications, but not unmodified proteins. (Ref.: Wagner, GR et al. (2017). Cell Metabolism 25(4); 823-837).

Specificity

This rabbit polyclonal antibody detects 3-methylglutaryl (MG)-lysine conjugated to BSA.

Immunogen

3-methylglutaryl (MG)-lysine conjugated to BSA.

Application

Anti-methylglutaryl-lysine, Cat. No. ABS2120, is a rabbit polyclonal antibody that detects 3-methylglutaryl-lysine conugated proteins and has been tested for use in Western Blotting.
Research Category
Signaling
Western Blotting Analysis: A representative lot detected methylglutaryl-lysine in Western Blotting applications (Wagner, G.R., et. al. (2017). Cell Metab. 25(4):823-837; Anderson, K.A., et. al. (2017). Cell Metab. 25(4):838-855.e15).

Quality

Evaluated by Western Blotting with methyl glutaryl BSA conjugate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected 3-methylglutaryl (MG)-lysine in methyl glutaryl BSA conjugate.

Target description

~75 kDa observed (BSA conjugate). Uncharacterized bands may be observed in some lysate(s).

Physical form

Affinity Purified
Format: Purified
Purified rabbit polyclonal antibody in PBS with 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Regulatory Information

新产品

    • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Elma Zaganjor et al.
    Cell reports, 36(2), 109345-109345 (2021-07-15)
    Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte differentiation. We find that adipocyte differentiation raises the uptake and consumption

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service