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Safety Information

ABS2120

Sigma-Aldrich

Anti-methylglutaryl-lysine

from rabbit

Synonym(s):

3-methylglutaryl (MG)-lysine, MG

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

all

packaging

antibody small pack of 25 μg

technique(s)

western blot: suitable

isotype

IgG

target post-translational modification

unmodified

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This Item
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Anti-methylglutaryl-lysine from rabbit

ABS2120

Anti-methylglutaryl-lysine

Anti-HMG-Lysine from rabbit

ABS2108

Anti-HMG-Lysine

Anti-Methylated Lysine antibody produced in rabbit affinity isolated antibody

SAB5200093

Anti-Methylated Lysine antibody produced in rabbit

Anti-Acetyl Lysine Antibody Chemicon®, from rabbit

AB3879

Anti-Acetyl Lysine Antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

technique(s)

western blot: suitable

technique(s)

western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

ELISA: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

packaging

antibody small pack of 25 μg

packaging

antibody small pack of 25 μL

packaging

-

packaging

-

antibody product type

primary antibodies

antibody product type

primary antibodies

antibody product type

primary antibodies

antibody product type

primary antibodies

General description

Acetylation of lysine residues is proteins has emerged as an important mechanism in regulation and coordination of normal and pathophysiological cell metabolism. Lysine 3-methylglutaryl is a newer post-translational protein modification that occurs under normal basal conditions. In murine models of HMG-CoA lyase deficiency, higher levels of protein lysine 3-MGylation are observed. This rabbit polyclonal antibody specifically detects chemically modified proteins containing 3-methylglutaryl lysine modifications, but not unmodified proteins. (Ref.: Wagner, GR et al. (2017). Cell Metabolism 25(4); 823-837).

Specificity

This rabbit polyclonal antibody detects 3-methylglutaryl (MG)-lysine conjugated to BSA.

Immunogen

3-methylglutaryl (MG)-lysine conjugated to BSA.

Application

Anti-methylglutaryl-lysine, Cat. No. ABS2120, is a rabbit polyclonal antibody that detects 3-methylglutaryl-lysine conugated proteins and has been tested for use in Western Blotting.
Research Category
Signaling
Western Blotting Analysis: A representative lot detected methylglutaryl-lysine in Western Blotting applications (Wagner, G.R., et. al. (2017). Cell Metab. 25(4):823-837; Anderson, K.A., et. al. (2017). Cell Metab. 25(4):838-855.e15).

Quality

Evaluated by Western Blotting with methyl glutaryl BSA conjugate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected 3-methylglutaryl (MG)-lysine in methyl glutaryl BSA conjugate.

Target description

~75 kDa observed (BSA conjugate). Uncharacterized bands may be observed in some lysate(s).

Physical form

Affinity Purified
Format: Purified
Purified rabbit polyclonal antibody in PBS with 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Regulatory Information

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