Anti-TTBK1 Antibody

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.

This antibody is predicted to not cross-react with TTBK2.

KLH-conjugated linear peptide corresponding to human TTBK1.

Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.

Evaluated by Western Blot in Jurkat cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTBK1 in 15 µg of Jurkat cell lysate.

~143 kDa observed

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Jurkat cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.