ABE1288
Anti-Nur77 Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... NR4A1(3164)
General description
Nurr77 is an internal nuclear receptor that is expressed developmentally and in the adult in many tissues including the liver, brain and thyroid. In the liver it acts along with other transcription factors to govern liver development as well as regeneration in the adult. Nur77 also participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Nur77 is also a potent pro-apoptotic protein, particularly in the brain and heart where translocation of Nur77 into the mitochondria where it induces apoptosis. Interestingly in certain cancers Nur77 overexpression is associated with pro-oncogenic activity and regulating energy levels which promotes proliferation and survival in cancer cells.
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human Nur77.
Application
Anti-Nur77 is an antibody against Nur77 for use in WB, ICC.
Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Nur77 in HEPG2 cells.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
Nuclear Receptors
Quality
Evaluated by Western Blotting in human liver tissue lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected Nur77 in 10 µg of human liver tissue lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected Nur77 in 10 µg of human liver tissue lysate.
Target description
~65 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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