ABD133
Anti-ACVR1B Antibody
from rabbit, purified by affinity chromatography
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Activin A receptor type IB, Activin receptor-like kinase 4, Activin receptor type 1B precursor, ACTR-IB, ACVRLK4, ALK4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ACVR1B(91)
General description
Activin receptor type-1B (ACVR1B) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. ACVR1B is known to form activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Within this receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors (including ACVR1B) act as downstream transducers of activin signals. Activins play role in many physiological and pathological processes including neuronal differentiation and neuronal survival, wound healing, extracellular matrix production, hair follicle development and cycling, FSH production, immunosuppression and carcinogenesis. ACVR1B is expressed highly in systemic sclerosis patient fibroblasts which suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. ACVR1B is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human ACVR1B.
Application
Anti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation
Pluripotent & Early Differentiation
Quality
Evaluated by Western Blotting/Peptide Inhibition Assay in human kidney tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate.
Target description
~70 kDa observed. Uniprot describes 5 isoforms ranging between ~52 kDa and ~62 kDa
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human kidney tissue lysate
Human kidney tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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