Skip to Content
Merck
CN
All Photos(2)

Documents

ABC470

Sigma-Aldrich

Anti-Kallikrein-5 Antibody/KLK5

from rabbit, purified by affinity chromatography

Sign Into View Organizational & Contract Pricing
All Photos(2)
Synonym(s):
Kallikrein-5, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, Kallikrein-5/KLK5
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

gorilla (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001070959

UniProt accession no.

Q9Y337

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KLK5(25818)

General description

Kallikrein-5/KLK5, or also known as Kallikrein-related peptidase 5, Kallikrein-like protein 2, KLK-L2, and formerly known as Stratum corneum tryptic enzyme (SCTE), is an important enzyme encoded by the gene KLK5/KLK-L2/SCTE. KLK5 is a secreted serine protease enzyme that is expressed in many tissues including the skin, breast and brain. In the skin, Kallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). KLK5 is considered as one of the most important KLKs in skin desquamation because KLK5 also regulates the activation of other Kallikreins needed for cell shedding. In disease, KLK5 displays aberrant expression in many cancers. However, expression of KLK5 in some cancer cells appears to suppress tumor growth and activity via reduced RhoA activity and the modulation the mevalonate pathway. This is particularly true in breast cancer and efforts are examining methods to increase KLK5 expression in breast cancer as a form of treatment.

Immunogen

KLH-conjugated linear peptide corresponding to the Peptidase S1 domain of human Kallikrein-5/KLK5.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-5/KLK5 in human skin cancer sections tissue.
This Anti-Kallikrein-5 Antibody/KLK5 is validated for use in Western Blotting and Immunohistochemistry for the detection of Kallikrein-5/KLK5.

Quality

Evaluated by Western Blotting in ovcar 3 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Kallikrein-5/KLK5 in 10 µg of ovcar 3 cell lysate.

Target description

~32 kDa observed

Other Notes

Concentration: Please refer to lot specific datasheet.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service