ABC324
Anti-PDL-1 Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
PDL-1 Antibody, PDL-1, Programmed cell death 1 ligand-1, programmed death ligand 1, PD-L1, B7-H1
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... CD274(29126)
General description
Programmed cell death 1 ligand 1 (PDL-1) is a B7 related protein belonging to the BTN/MOG family. PDL-1 is essential for T-cell proliferation and production of IL10 and IFNG. PDL-1 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PDL-1 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PDL-1 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver.
Immunogen
KLH-conjugated linear peptide corresponding to human PDL-1.
Application
Anti-PDL-1 Antibody is a highly specific rabbit polyclonal antibody, that targets Programmed cell death 1 ligand 1 & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PDL-1 in human heart tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PDL-1 in human heart tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PDL-1 in human heart tissue.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Quality
Evaluated by Western Blotting in Raji cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1 in 15 µg of Raji cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1 in 15 µg of Raji cell lysate.
Target description
~30 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and 1 at ~33 kDa
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Raji cell lysate
Raji cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lian Zhao et al.
Oncotarget, 7(29), 45370-45384 (2016-06-02)
microRNAs (miRNAs) play critical roles in cancer development and progression. This study investigated the effects of miR-138-5p in human colorectal cancer (CRC) development. miR-138-5p was frequently downregulated in CRC tissues and was associated with advanced clinical stage, lymph node metastasis
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