AB9916
Anti-CYP2b10 Antibody
serum, Chemicon®
Synonym(s):
Cytochrome P450 2b10
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Cyp2B10(13088)
Related Categories
General description
CYP2b10 (Cytochrome P450, family 2, subfamily b, polypeptide 10) is a member of the cytochrome P450 superfamily of monooxygenase enzymes which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
Specificity
AB9916 is specific for CYP2b10.
Immunogen
Epitope: AA I182 – T205
Recombinant 2b10
Application
This Anti-CYP2b10 Antibody is validated for use in WB for the detection of CYP2b10.
Quality
Routinely evaluated by immunoblot.
Target description
58kDa
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 1
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Shinhee Park et al.
Acta pharmaceutica Sinica. B, 6(5), 475-491 (2016-10-07)
Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect in intestine. Sixty-day-old
Cindy Yanfei Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 153(2), 282-302 (2016-07-15)
Safety concerns have emerged regarding the potential long-lasting effects due to developmental exposure to xenobiotics. The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are critical xenobiotic-sensing nuclear receptors that are highly expressed in liver. The goal of this
Kentaro Nobutani et al.
Pharmacology research & perspectives, 5(5) (2017-10-04)
Herbal medicines and natural products used for maintenance of health or treatment of diseases have many biological effects, including altering the pharmacokinetics and metabolism of other medications. Daikenchuto (TU-100), an aqueous extract of ginger, ginseng, and Japanese green pepper fruit
Cindy Yanfei Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(7), 1038-1049 (2015-11-19)
The xenobiotic-sensing transcription factors (xeno-sensors) AhR, CAR, and PXR upregulate the expression of many drug-processing genes (DPGs) in liver. Previous studies have unveiled profound changes in the basal expression of DPGs during development; however, knowledge on the ontogeny of the
Hemantkumar Chavan et al.
The Journal of biological chemistry, 290(12), 7871-7886 (2015-01-28)
Although endogenous mechanisms that negatively regulate cytochrome P450 (P450) monooxygenases in response to physiological and pathophysiological signals are not well understood, they are thought to result from alterations in the level of endogenous metabolites, involved in maintaining homeostasis. Here we
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