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biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... QKI(9444)
General description
QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.
Specificity
QKI-5 (Quaking Protein). The antibody recognizes the ~40 kDa protein.
Immunogen
Synthetic peptide from mouse QKI-5.
Application
Detect QKI-5 using this Anti-QKI-5 Antibody validated for use in IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
RNA Binding Protein (RBP)
Developmental Neuroscience
RNA Binding Protein (RBP)
Target description
~40 kDa
Physical form
Liquid.
Serum
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
Positive Control: Glial cells, astrocytes and oligodendrocytes.
Positive Control: Glial cells, astrocytes and oligodendrocytes.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Xingyu Yang et al.
Journal of cellular and molecular medicine, 25(12), 5655-5670 (2021-05-05)
Preeclampsia (PE) is characterized by placental ischemia and hypoxia, resulting in abnormal casting of the uterine spiral artery, which is mainly caused by insufficient trophoblastic cell infiltration. A reduction in levels of growth factor-based signalling via Neuropilin-1 (NRP1) has been
Fang Wang et al.
Cell research, 27(3), 416-439 (2017-03-01)
MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and
Benjamin Rauwel et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(4), 753-765 (2019-12-14)
Increased osteoclastogenesis is a common feature of bone erosion, notably in osteoporosis but also in inflammatory diseases such as rheumatoid arthritis (RA) and osteoarticular infections. Human cytomegalovirus (HCMV) infection has been described to impair monocyte differentiation into macrophages and dendritic
Jiao Du et al.
Journal of cellular and molecular medicine, 24(24), 14231-14246 (2020-11-01)
Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one of the primary causes of cerebrovascular and cardiovascular events. Neovascularization within the plaque is closely associated with its stability. Long non-coding RNA (lncRNA) serves a crucial role in
Kai Li et al.
Cell death & disease, 10(10), 699-699 (2019-09-22)
Spermatogenesis is the complex process of male germline development and requires coordinated interactions by multiple gene products that undergo strict developmental regulations. Increasing evidence has suggested that a number of long noncoding RNAs (lncRNAs) may function as important regulatory molecules
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