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AB980

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody

Synonym(s):

Myelin A1 protein, Myelin membrane encephalitogenic protein

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702

biological source

rabbit

antibody form

purified antibody

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

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This Item
GF91798543GF37454913GF15970080
form

foil

form

foil

form

foil

form

foil

assay

99.99%

assay

≥99.99%

assay

99.99%

assay

99.99%

resistivity

12.7 μΩ-cm, 20°C

resistivity

12.7 μΩ-cm, 20°C

resistivity

12.7 μΩ-cm, 20°C

resistivity

12.7 μΩ-cm, 20°C

bp

2672 °C (lit.)

bp

2672 °C (lit.)

bp

2672 °C (lit.)

bp

2672 °C (lit.)

mp

1857 °C (lit.)

mp

1857 °C (lit.)

mp

1857 °C (lit.)

mp

1857 °C (lit.)

General description

The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

Specificity

Suitable for labeling of oligodendrocytes and myelin of white matter in brain and spinal cord (gray matter stains less abundantly). Also stains peripheral nerves.

Immunogen

Human myelin basic protein from brain

Application

Immunohistochemistry:
1:200 dilution of a previous lot was used by PAP or ABC on formalin fixed, paraffin-embedded human spinal cord. Pretreatment of tissue with proteolytic enzyme is not required.

Western Blot:
A dilution of 1:3000 was used in TTBS, O/N 4°C on a previous lot.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers|Neurochemistry & Neurotrophins
This Anti-Myelin Basic Protein Antibody is validated for use in IH, IH(P), WB for the detection of Myelin Basic Protein.

Quality

Evaluated by Western Blot on Mouse brain lysates.

Western Blot Analysis:
1:500 dilution of this antibody detected four isoforms of MBP on 10 μg of Mouse brain lysates.

Target description

21, 18, 17 & 14 kDa.

Physical form

Liquid in 0.05 mol/L Tris-HCl, pH 7.6 with 15 mmol/L sodium azide.

Format: Purified Ammonium Sulfate Precipitation

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
Brain tissue, brain lysate

Other Notes

Concentration:Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class Code

10-13 - German Storage Class 10 to 13

Regulatory Information

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