Anti-Stabilin-1 Antibody, CT

Stabilin-1 and Stabilin-2 constitute a novel family of fasciclin domain-containing hyaluronan receptor homologs that may play a role in cell-cell and cell-extracellular matrix interactions in vascular function and inflammatory processes. Stabilin-1 is a transmembrane protein, expressed in endothelial cells within the sinusoidal regions of liver, spleen, and lymph tissues as well as macrophages. Stabilin-2 is absent from the latter (Politz, 2002).

Other notable species homologies include mouse (87%) and rat (83%).

The antibody recognizes the C-terminus of Stabilin-1 within the cytoplasmic region of a cell.

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human Stabilin-1.

Anti-Stabilin-1 Antibody, C-terminus is an antibody against Stabilin-1 for use in WB, IH(P) & IF.

Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Stabilin-1 in human placental tertiary villi.
Immunofluorescence Analysis: A previous lot of Anti-Stabilin-1, C-terminus was shown to positively stain using immunofluorescence techniques (Kzhyshkowska, 2008).

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Evaluated by Western blot in HUVEC lysate.
Western blot Analysis: 1:1,000 dilution of this antibody detected Stabilin-1 on 10 µg of HUVEC lysate.

~ 275 kDa

Format: Unpurified

Unpurified

Unpurified rabbit polyclonal in serum with 0.05% sodium azide.

Stable for 1 year at -20°C from date of receipt if stored in undiluted aliquots.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Control
HUVEC lysate.

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