AB5864
Anti-Myelin Basic Protein Antibody
serum, Chemicon®
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All Photos(2)
Synonym(s):
MBP
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... MBP(4155)
rat ... Mbp(24547)
Specificity
Recognizes Myelin Basic Protein in demyelinated nerve tissues. Immunohistochemistry analysis of lesioned rat spinal cord shows a high level of specificity for this antiserum.
Immunogen
Synthetic peptide corresponding to amino acids 69-86 of the guinea pig protein. Immunogen corresponds to "degraded" Myelin Basic Protein: YGSLPQKSQRSQDENPVV
Application
Anti-Myelin Basic Protein Antibody is an antibody against Myelin Basic Protein for use in IH.
Immunohistochemistry: 1:2,000. Immunostains myelin basic protein of abnormal appearing oligodendrocytic processes and cell bodies in demyelinating areas. The antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve. It also stains discrete white matter in brain of multiple system atrophy
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuronal & Glial Markers
Neurodegenerative Diseases
Neuronal & Glial Markers
Neurodegenerative Diseases
Physical form
Rabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.
Unpurified
Storage and Stability
Maintain at -20 to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Analysis Note
Control
Brain tissue
Brain tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Brian D Clark et al.
Journal of neurotrauma, 20(7), 681-695 (2003-08-12)
Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by
Role of myelin auto-antigens in pain: a female connection.
Veronica I Shubayev et al.
Neural regeneration research, 11(6), 890-891 (2016-08-03)
Andriy O Glushakov et al.
International journal of molecular sciences, 19(10) (2018-10-17)
Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic neurological complications including problems with cognition, motor function, sensory processing, as well as behavioral deficits and mental health problems such as anxiety, depression, personality change and social unsuitability.
James Rice et al.
Acta neuropathologica communications, 7(1), 173-173 (2019-11-11)
Adolescent binge drinking represents a major public health challenge and can lead to persistent neurological and mental conditions, but the underlying pathogenic mechanisms remain poorly understood. Using a mouse model of adolescent binge ethanol treatment (ABET), we found that this
Maria L Allende et al.
Journal of lipid research, 59(3), 550-563 (2018-01-24)
Sandhoff disease, one of the GM2 gangliosidoses, is a lysosomal storage disorder characterized by the absence of β-hexosaminidase A and B activity and the concomitant lysosomal accumulation of its substrate, GM2 ganglioside. It features catastrophic neurodegeneration and death in early
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