AB2266
Anti-VPAC2 Antibody
from rabbit, purified by affinity chromatography
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All Photos(2)
Synonym(s):
vasoactive intestinal peptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, vasoactive intestinal polypeptide receptor 2, PACAP type III receptor
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
pig (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... VIPR2(7434)
General description
Vasoactive intestinal polypeptide receptor 2 (VPAC2), also known as PACAP type III receptor or PACAP-R3 for short, is a class B G-protein-coupled receptor. Three distinct PACAP receptors have been identified. Of the three, only PACAP-3 has been found expressed in Sartoli cells of the testis and is coupled to G and adenylyl cyclase, thus having a potential influence on the production of cAMP. In the immune system, PACAP-R3 is expressed on stimulated CD4 T cells, and binding of T cell-derived VIP to-PACAP-R3 induces a shift toward the Th2 pathway. In addition, PACAP-R3 is an essential regulator of the circadian pacemaker of the hypothalamic suprachiasmatic nuclei (SCN).
Specificity
Other homologies: mouse (84% sequence homology).
This antibody recognizes VCAP2 (PACAP-R3) at the extracellular domain.
Immunogen
KLH-conjugated linear peptide corresponding to the extracellular domain of human VPAC2 (PACAP-R3).
Application
Anti-VPAC2 Antibody is an antibody against VPAC2 for use in WB, IH(P).
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected VPAC2 in normal human cerebral cortex and T cells inside the mantle zone of normal human tonsil tissues.
Quality
Evaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected VPAC2 on 10 µg of Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected VPAC2 on 10 µg of Jurkat cell lysate.
Target description
~52 kDa observed. An uncharacterized band appears at ~39 kDa in some lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Liwen Chen et al.
Investigative ophthalmology & visual science, 59(7), 2848-2860 (2018-07-20)
To investigate the roles of vasoactive intestinal peptides (VIPs) in regulating the morphology and F-actin distribution of Schlemm's canal (SC) of rat eyes. Chronic intraocular pressure (IOP) hypertension models with episcleral venous cauterization (EVC) were treated with topical VIP or
Xiaoqin Yan et al.
Investigative ophthalmology & visual science, 61(6), 45-45 (2020-06-24)
A previous study reported that vasoactive intestinal peptide (VIP) can regulate the cytoskeleton of Schlemm's canal (SC) endothelium and expand the SC lumen in a rat glaucoma model. In this study, we aimed to investigate the molecular mechanism of VIP
Jayden Lee et al.
International journal of molecular sciences, 24(13) (2023-07-14)
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most common and severe manifestations of lupus; however, its pathogenesis is still poorly understood. While there is sparse evidence suggesting that the ongoing autoimmunity may trigger pathogenic changes to the central
Ana Florencia Vega-Benedetti et al.
International journal of molecular sciences, 21(12) (2020-07-01)
Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for its prevention and treatment. Since DNA methylation alterations are early events in tumourigenesis and can be detected in cell-free DNA, they represent promising biomarkers for
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