AB2265
Anti-VPAC1 Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
Vasoactive intestinal polypeptide receptor 1, Pituitary adenylate cyclase-activating polypeptide type II receptor, vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... VIPR1(7433)
General description
The vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1 (VPAC1) is a member of a class II subfamily of G-protein-coupled receptors and has a high affinity for vasoactive intestinal peptide (VIP). VPAC1 has been associated with many different lung cancer cell lines. VPAC1 is thought to be activated by FXR and may contribute to the regulation of bile secretion to protect against gallstone disease. VPAC1 could be used to regulate VIPs and, in turn, inhibit breast cancer growth. VPAC1 has also been implicated in regulation of the anti-inflammatory effects of VIP.
Specificity
This antibody recognizes VPAC1 at the cytoplasmic domain.
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of VPAC1.
Application
Anti-VPAC1 Antibody detects level of VPAC1 & has been published & validated for use in IH(P) & WB.
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected VPAC1 in ovarian carcinoma tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Hormones & Receptors
Hormones & Receptors
Quality
Evaluated by Western Blot in SK-OV-3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPAC1 on 10 µg of SK-OV-3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPAC1 on 10 µg of SK-OV-3 cell lysate.
Target description
~52 kDa observed. Multiple molecular weights of VPAC1 may be due to glycosylation. (Fabre, C, et al. (1993). Peptides. 14:483-489.)
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
SK-OV-3 cell lysate
SK-OV-3 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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