AB2255
Anti-GABA B Receptor R2 Antibody
serum, from guinea pig
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
guinea pig
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rhesus macaque, rat
species reactivity (predicted by homology)
canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GABBR2(9568)
General description
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
Specificity
This antibody recognizes the C-terminus of rat GABA-B-R2.
Immunogen
Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.
Application
Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB.
Quality
Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.
Target description
Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present.
Linkage
Replaces: AB5394
Analysis Note
Control
Purkinje cells in rat mid-brain region
Purkinje cells in rat mid-brain region
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Liang Zhang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(6), 1467-1476 (2015-10-27)
Cortical network hyper-excitability is a common phenotype in mouse models lacking the transcriptional regulator methyl-CPG-binding protein 2 (MeCP2). Here, we implicate enhanced GABAB receptor activity stemming from diminished cortical expression of the GABA transporter GAT-1 in the genesis of this
Yupeng Miao et al.
Nature communications, 12(1), 4518-4518 (2021-07-28)
Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017
Chuanyin Hu et al.
Molecular medicine reports, 15(2), 975-980 (2016-12-31)
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established
Khaled Zemoura et al.
The Journal of biological chemistry, 291(41), 21682-21693 (2016-08-31)
GABAB receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABAB receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell surface expression of
Emilia Favuzzi et al.
Cell, 184(15), 4048-4063 (2021-07-08)
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service