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AB1623

Sigma-Aldrich

Anti-Histone H2B Antibody

serum, Chemicon®

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UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_175055.2

UniProt accession no.

Q8N257

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... H2BC1(255626)

Specificity

Reacts with histone H2B in human nuclear fractions. No cross-reactivity with other histones, H1, H2A, H3 or H4. Binding of histones from other species has not been tested, but it is likely as the amino acid sequence of histone H2B has been found to be identical in all species examined.

Immunogen

Synthetic peptide

Application

Detect Histone H2B also known as Histone H2B with Anti-Histone H2B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB & IHC.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones
Western blot

Immunohistochemistry on paraformaldehyde treated sections.

Optimal working dilutions must be determined by end user.

Linkage

Replaces: MABE15

Physical form

Rabbit antiserum. Liquid. Contains no preservative.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ricardo Martinez-Zamudio et al.
Molecular and cellular biology, 32(13), 2490-2502 (2012-05-02)
The packaging of DNA into nucleosomes imposes obstacles on gene transcription, and histone-modifying and nucleosome-remodeling complexes work in concert to alleviate these obstacles so as to facilitate transcription. Emerging evidence shows that chromatin-associated poly(ADP-ribose) polymerase 1 (PARP-1) and its enzymatic
Siwei Ouyang et al.
Neurobiology of aging, 36(10), 2850-2860 (2015-08-11)
The progressive loss of neurons causes neurodegenerative diseases. Because the accumulation of DNA breaks results in neuronal apoptosis, the lack of a variety of DNA damage repair-related proteins contributes to neurodegeneration. The ubiquitin ligase RNF8 plays an important role in

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