AB1585
Anti-Dopamine β Hydroxylase Antibody
serum, Chemicon®
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All Photos(3)
Synonym(s):
DBH, Dopamine beta-monooxygenase
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
bovine, guinea pig, rat, human, feline, rabbit
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
radioimmunoassay: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... DBH(1621)
Specificity
Recognizes Dopamine beta hydroxylase. AB1585 reacts with a single band on Western blots of bovine adrenal homogenates and stains only cells known to contain DBH, such as sympathetic neurons, adrenal medullary cells and central adrenergic neurons. Staining is abolished by preincubation with enzyme.
Immunogen
Native enzyme from bovine adrenal glands.
Application
Detect Dopamine β Hydroxylase using this Anti-Dopamine β Hydroxylase Antibody validated for use in IH, FUNC, RIA & WB.
Immunohistochemistry: 1:2,000 on rabbit and guinea pig using an ABC detection method.
Western blot
RIA
Inhibitory studies in vivo and in vitro.
Optimal working dilutions must be determined by the end user.
Western blot
RIA
Inhibitory studies in vivo and in vitro.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neuronal & Glial Markers
Neurotransmitters & Receptors
Neuronal & Glial Markers
Target description
69 kDa
Linkage
Replaces: AB145
Physical form
Rabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material.
Unpurified
Storage and Stability
Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. Glycerol can be added 1:1 for additional stability.
Analysis Note
Control
Brain (Striatum/Substantia Nigra)
Brain (Striatum/Substantia Nigra)
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
recommended
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Directed differentiation of neural cells to hypothalamic dopaminergic neurons.
Ohyama, K; Ellis, P; Kimura, S; Placzek, M
Development null
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Programmed cell death occurs naturally at different stages of neural development, including neurogenesis. The functional role of this early phase of neural cell death, which affects recently differentiated neurons among other cell types, remains undefined. Some mouse models defective in
Jian Qi et al.
PloS one, 6(8), e23275-e23275 (2011-08-23)
The synaptic connections between neurokinin 1 (NK1) receptor-like immunoreactive (LI) neurons and γ-aminobutyric acid (GABA)-, glycine (Gly)-, serotonin (5-HT)- or dopamine-β-hydroxylase (DBH, a specific marker for norepinephrinergic neuronal structures)-LI axon terminals in the rat medullary dorsal horn (MDH) were examined
Junchao Tong et al.
Journal of neurochemistry, 102(5), 1691-1702 (2007-05-09)
We recently identified a noradrenaline-rich caudomedial subdivision of the human nucleus accumbens (NACS), implying a special function for noradrenaline in this basal forebrain area involved in motivation and reward. To establish whether the NACS, as would be expected, contains similarly
D M Buffalari et al.
Neuroscience, 281, 241-250 (2014-07-23)
Central noradrenergic (NA) signaling contributes critically to multiple behavioral effects of cocaine administration, particularly stress- and anxiety-related effects. The present study examined the ability of acute cocaine to induce the immediate early gene product, cFos, in NA neurons and stress-related
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