Anti-Nogo Receptor Antibody

Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

Cat. # AB15138 recognizes the mature form of Nogo Receptor.

May react with human and primate based on sequence homology. Reactivity with other species has not been determined.

Epitope: Mature Form

Recombinant protein.

Anti-Nogo Receptor Antibody detects level of Nogo Receptor & has been published & validated for use in WB, IH.

Non-Lot Specific Tested Application 1:
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)

Research Category
Neuroscience

Research Sub Category
Growth Cones & Axon Guidance

Routinely tested on mouse cerebellum lysate.
Lot Specific Tested Application 1: Western Blot

~50.9 kDa

Format: Purified

Protein A purified

Purified in PBS with 0.1% NaN3

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Control
Mouse cerebellum lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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