Anti-Neurotensin Receptor 2 Antibody

Neurotensin Receptor 2 (NTR2) is a member of the G-protein coupled receptor family. Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents (Kinkead and Nemeroff, 2004). In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin (Castagliuolo et al., 1999). The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR2 recognizes a histamine H1 receptor antagonist that had been shown to compete with neurotensin for low-affinity binding sites in the brain.

This antibody recognizes Neurotensin Receptor 2.

Epitope: Extracellular Domain

KLH-conjugated linear peptide from the extracellular domain of human Neurotensin Receptor 2.

Detect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.

Research Category
Neuroscience

Metabolism

Research Sub Category
Neurotransmitters & Receptors

Hormones & Receptors

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of mouse brain lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of rat brain lysate.

Evaluated by Western Blot in human cortex lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of human cortex lysate.

45.413 kDa is the calculated molecular weight. In Western Blot, immunoreactive bands which might reflect multimeric species of Neurotensin Receptor 2, are detected at approximately 60-65 kDa, 75 kDa, and 80-85 kDa Sarret, P., et al. (2003). J Comp Neurol. 461(4):520-538.

Replaces: AB9521

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human cortex lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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