All Photos(1)
Synonym(s):
BCL2 binding component 3, Bcl-2 binding component 3, p53 up-regulated modulator of apoptosis
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Bbc3(170770)
General description
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis
Specificity
Other species have not been tested.
The antibody reacts with the 21 kDa Puma BH3 domain protein.
Immunogen
This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.
Application
Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.
Quality
Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.
Target description
21 kDa
Physical form
Format: Purified
Analysis Note
Control
Western Blot : Mouse brain lysate
Western Blot : Mouse brain lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Bhargab Kalita et al.
PloS one, 11(12), e0168525-e0168525 (2016-12-31)
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