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8.55134

Sigma-Aldrich

Ramage Amide AM resin

Novabiochem®

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Synonym(s):
2-{[(R,S)-5-(9-Fluorenylmethyloxycarbonyl-amino)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-2-yl]oxy}acetyl-AM resin
UNSPSC Code:
12352111
NACRES:
NA.22

Quality Level

200

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

Related Categories

General description

Ramage Amide AM resin comprises Ramage′s dibenzocycloheptadienelinker [1] attached to aminomethylated polystyrene. Following Fmoc removal, the resin can be acylated under standard conditions and used in Fmoc SPPS. The linker is considerably more acid sensitive than the Rink amide or PAL linkers. This enables peptide amides to be released from the resin with 3% TFA in DCM and thus makes it a useful tool for the synthesis of acid sensitive peptides or protected peptide fragments.


Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] R. Ramage, et al. (1993) Tetrahedron Lett., 34, 6599.

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocols

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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