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8.55008

Sigma-Aldrich

Sieber Amide resin

Novabiochem®

Synonym(s):

Sieber Amide resin, 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin

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500 G
CN¥2,444.35

CN¥2,444.35

Available to ship onApril 23, 2025Details

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500 G
CN¥2,444.35

About This Item

CAS Number:
915706-90-0
MDL number:
MFCD00039239
UNSPSC Code:
12352111
NACRES:
NA.22

CN¥2,444.35

Available to ship onApril 23, 2025Details

Sign In for Best Price
Request a Bulk Order

Quality Level

400

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

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This Item
D5287D7400B5002
2′-Deoxyuridine ≥98.5%

D5412

2′-Deoxyuridine

2′-Deoxyinosine ≥98%

D5287

2′-Deoxyinosine

2′-Deoxyadenosine monohydrate ≥99%

D7400

2′-Deoxyadenosine monohydrate

5-Bromo-2′-deoxyuridine ≥99% (HPLC)

B5002

5-Bromo-2′-deoxyuridine

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥98.5%

assay

≥98%

assay

≥99%

assay

≥99% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

solubility

water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

DMSO: 50 mg/mL, clear, colorless to very faintly yellow

impurities

Thymidine, free

impurities

inosine, essentially free

impurities

-

impurities

-

General description

A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage [1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides [3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4] .

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

  • Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023).
  • Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017).
  • A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).

Linkage

Replaces: 01-64-0059

Analysis Note

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

    • Certificates of Analysis (COA)

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    Articles

    Fmoc SPPS Linkers

    Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

    Protocols

    Peptide Resin Loading Protocols

    Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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