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8.55004

Sigma-Aldrich

Rink Amide AM resin (200-400 mesh)

Novabiochem®

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Synonym(s):
4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucylaminomethyl resin
UNSPSC Code:
12352111
NACRES:
NA.22

Quality Level

400

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-30°C

Related Categories

General description

This support comprises the modified Rink amide linker attached via norleucine to aminomethylpolystyrene, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application


  • Second generation amphiphilic poly-lysine dendrons inhibit glioblastoma cell proliferation without toxicity for neurons or astrocytes: Uses Rink Amide AM resin with a 0.71mmol/g loading capacity for synthesizing amphiphilic dendritic amides. (Janiszewska et al., 2016).

  • The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides: Describes peptide synthesis on Rink Amide AM resin with a 0.79 mmol/g loading capacity. (Eggimann et al., 2015).

Linkage

Replaces: 01-64-0038

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.1 ml/g
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene-1 % DVB), 200 -400 mesh.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocols

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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