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Key Documents

Safety Information

8.52378

Sigma-Aldrich

Fmoc-Phe(SO3Na)-OH

Novabiochem®

Synonym(s):

Fmoc-Phe(SO3Na)-OH, N-α-Fmoc-4-sulfophenylalanine sodium salt

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1 EA
CN¥6,780.43

CN¥6,780.43

Available to ship onApril 27, 2025Details

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About This Item

Empirical Formula (Hill Notation):
C24H20NNaO7S
Molecular Weight:
489.47
UNSPSC Code:
12352209
NACRES:
NA.22

CN¥6,780.43

Available to ship onApril 27, 2025Details

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Request a Bulk Order

Quality Level

200

product line

Novabiochem®

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

sulfonic acid

storage temp.

15-25°C

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Fmoc-Phe(SO3Na)-OH Novabiochem®

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852288

Fmoc-Phe(CF2PO3)-OH

Fmoc-Tyr(SO3nP)-OH Novabiochem®

852347

Fmoc-Tyr(SO3nP)-OH

form

powder

form

powder

form

powder

form

powder

functional group

sulfonic acid

functional group

Fmoc

functional group

Fmoc

functional group

sulfonic acid

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

General description

Introduction of 4-sulfo-phenylalanine is an effective strategy for increasing solubility of a peptide. This amino acid has also been employed in analogs of angiotensin 2 [1], phytosulfokine [2], and cyclolinopeptide A [3]. Its incorporation during solid phase synthesis using Fmoc-Phe(SO3Na)-OH is best carried out with base-mediated coupling methods such as PyBOP® or HBTU.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] E. Escher, et al. (1983) , 66, 1355.
[2] A. Bahyrycz, et al. (2004) , 10, 462.
[3] Y. Fujiwara, et al. (1994) , 42, 724.

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): -17.0 - -15.0 °
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Purity TLC (BAW 1): ≥ 97.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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