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8.52375

Sigma-Aldrich

Fmoc-hLys(Boc)-OH

Novabiochem®

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Synonym(s):
Fmoc-hLys(Boc)-OH, N-α-Fmoc-N-ω-t.-Boc-L-homolysine
Empirical Formula (Hill Notation):
C27H34N2O6
CAS Number:
194718-17-7
Molecular Weight:
482.57
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

200

product line

Novabiochem®

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

InChI

1S/C27H34N2O6/c1-27(2,3)35-25(32)28-16-10-4-5-15-23(24(30)31)29-26(33)34-17-22-20-13-8-6-11-18(20)19-12-7-9-14-21(19)22/h6-9,11-14,22-23H,4-5,10,15-17H2,1-3H3,(H,28,32)(H,29,33)(H,30,31)/t23-/m0/s1

InChI key

CLFMIWUWBOOJLY-QHCPKHFHSA-N

Related Categories

General description

This homolog of lysine has been used to modulate ion-pairing interactions between Lys and enzyme carboxylate groups in SAR studies [1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] K. J. Kennedy, et al. (1997) Bioorg. Med. Chem. Lett., 7, 1937.

Application

Fmoc-hLys(Boc)-OH can be used as a building block in the solid phase peptide synthesis.

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Probing the flexibility of the catalytic nucleophile in the lyase catalytic pocket of human DNA polymerase β with unnatural lysine analogues
Daskalova SM, et al.
Biochemistry, 56(3), 500-513 (2017)
Exploring the impact of the side-chain length on peptide/RNA binding events
Sbicca L, et al.
Physical Chemistry Chemical Physics, 19(28), 18452-18460 (2017)

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