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8.52246

Sigma-Aldrich

Fmoc-D-Tyr(PO(OBzl)OH)-OH

Novabiochem®

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Synonym(s):
Fmoc-D-Tyr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-D-phosphotyrosine
Empirical Formula (Hill Notation):
C31H28NO8P
Molecular Weight:
573.53
UNSPSC Code:
12352209

Quality Level

200

product line

Novabiochem®

Assay

≥87.0% (acidimetric)
≥90.0% (HPLC)
≥95% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

General description

An excellent building block for the preparation of D-phosphotyrosine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOP® and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Fmoc SPPS of Peptides containing Post-Translational Modifications

Linkage

Replaces: 04-13-1080

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): +14.0 - +18.0 °
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 87.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.3 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Protocols

Building Blocks for Introducing Post-translational Modified Amino Acids

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service