Skip to Content
Merck
CN
All Photos(1)

Documents

8.52104

Sigma-Aldrich

Fmoc-Asp(OMpe)-OH

Novabiochem®

Sign Into View Organizational & Contract Pricing

Synonym(s):
Fmoc-Asp(OMpe)-OH, N-α-Fmoc-(O-3-methyl-pent-3-yl)aspartic acid
Empirical Formula (Hill Notation):
C25H29NO6
CAS Number:
Molecular Weight:
439.50
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

form

solid

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

carboxylic acid

storage temp.

15-25°C

InChI

1S/C25H29NO6/c1-4-25(3,5-2)32-22(27)14-21(23(28)29)26-24(30)31-15-20-18-12-8-6-10-16(18)17-11-7-9-13-19(17)20/h6-13,20-21H,4-5,14-15H2,1-3H3,(H,26,30)(H,28,29)/t21-/m0/s1

InChI key

SYGKUYKLHYQKPL-NRFANRHFSA-N

General description

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides [1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group [1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
[2] M. Mergler (2003) J. Pept. Sci., 9, 518.

Linkage

Replaces: 04-12-1259

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Aspartimide formation 1,2 is caused by repeated exposure of aspartic acid-containing sequences to bases like piperidine and can result ultimately in the generation of 9 different by-products.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service