8.52102
Fmoc-Glu(biotinyl-PEG)-OH
≥97% (TLC), for peptide synthesis, Novabiochem®
Recommended Products
Quality Level
product line
Novabiochem®
Assay
≥95.0% (HPLC)
≥97% (TLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
biotin
storage temp.
2-8°C
InChI
1S/C40H55N5O10S/c46-35(14-6-5-13-34-37-33(26-56-34)43-39(50)45-37)41-17-7-19-52-21-23-54-24-22-53-20-8-18-42-36(47)16-15-32(38(48)49)44-40(51)55-25-31-29-11-3-1-9-27(29)28-10-2-4-12-30(28)31/h1-4,9-12,31-34,37H,5-8,13-26H2,(H,41,46)(H,42,47)(H,44,51)(H,48,49)(H2,43,45,50)/t32-,33-,34-,37-/m0/s1
InChI key
MGOWNVYDCIBVKC-FNHRVDEZSA-N
Related Categories
General description
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Biotinylation Reagents for Peptide Synthesis
Literature references
[1] B. Baumeister, et al. (2003) Biopolymers, 71, 339.
[2] X. Zhou et al., (2004) J. Am. Chem. Soc., 126, 15656.
[3] B. F. Gilmore, et al. (2006) Biochem. Biophys. Res. Commun,, 347, 373.
[4] C. T. Archer, et al. (2005) Mol. BioSyst., 1, 366.
Application
- Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells: Utilized Fmoc-Glu(biotinyl-PEG)-OH in the synthesis protocol for peptoid libraries, contributing to biomarker discovery in lung cancer research (AC Raymond et al., 2019).
- Identification of side arm-modified DOTA scaffolds as multi-site binding ligands for cancer cells over normal cells: Included Fmoc-Glu(biotinyl-PEG)-OH in a synthesis protocol to enhance biotinylated scaffold properties for selective cancer cell targeting (V Rustagi, DG Udugamasooriya, 2019).
- TANGO-inspired design of anti-amyloid cyclic peptides: Employed Fmoc-Glu(biotinyl-PEG)-OH in the synthesis of cyclic peptides aimed at studying amyloid protein interactions, crucial for Alzheimer′s disease research (X Lu, RM Murphy, 2016).
- Converting a weaker ATP-binding site inhibitor into a potent hetero-bivalent ligand by tethering to a unique peptide sequence derived from the same kinase: Used Fmoc-Glu(biotinyl-PEG)-OH in developing new kinase inhibitors with improved binding properties (SR Kedika, DG Udugamasooriya, 2018).
Linkage
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (0,2 mmol in 1 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Regulatory Information
Certificates of Analysis (COA)
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Articles
Biotin-labelled peptides find applications in immunology and histochemistry for affinity purification and receptor localization.
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