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8.52101

Sigma-Aldrich

Fmoc-Arg(Boc)₂-OH

Novabiochem®

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Synonym(s):
Fmoc-Arg(Boc)₂-OH, N-α-Fmoc-N-ω,N-ωÆ-bis-t-butoxycarbonyl-L-arginine
Empirical Formula (Hill Notation):
C31H40N4O8
CAS Number:
Molecular Weight:
596.67
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

Assay

≥90.0% (acidimetric)
≥91.0% (HPLC)
≥95% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Boc
Fmoc

storage temp.

15-25°C

InChI

1S/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1

InChI key

WPAALELGEWGQEG-DEOSSOPVSA-N

General description

An excellent derivative for Fmoc SPPS of Arg-containing peptides [1]. Coupling of this derivative can be effected using standard activation methods, such as PyBOP® or TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1]
A. S. Verdini, et al. (1992) Tetrahedron Lett., 33, 6541.

Linkage

Replaces: 04-12-1249

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 98.5 % (a/a)
Purity (TLC(011A)): ≥ 95 %
Assay (HPLC, area%): ≥ 91.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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