8.52008
Fmoc-Cys(Trt)-OH
Novabiochem®
Synonym(s):
Fmoc-Cys(Trt)-OH, N-α-Fmoc-S-trityl-L-cysteine
About This Item
Recommended Products
Quality Level
product line
Novabiochem®
Assay
≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
mp
164-175 °C
application(s)
peptide synthesis
functional group
thiol
storage temp.
−20°C (−15°C to −25°C)
1 of 4
This Item | 466190 | T1199 | 45979 |
|---|---|---|---|
| assay ≥99.5% (GC) | assay 98% | assay - | assay - |
| solubility H2O: slightly soluble | solubility H2O: slightly soluble | solubility - | solubility H2O: slightly soluble |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form liquid | form liquid | form - | form - |
| mp −28 °C (lit.) | mp −28 °C (lit.) | mp - | mp −28 °C (lit.) |
| density 1.008 g/mL at 25 °C (lit.) | density 1.008 g/mL at 25 °C (lit.) | density - | density 1.008 g/mL at 25 °C (lit.) |
General description
Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
[2] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
[3] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307.
[4] Y. N. Angell (2002) J. Peptide Res., 5, 292.
Application
- On-resin synthesis of cyclic peptides via tandem N-to-S acyl migration and intramolecular thiol additive-free native chemical ligation: Discusses the use of Fmoc-Cys(Trt)-OH in the synthesis of cyclic peptides, highlighting the efficiency of the resin synthesis method. (Serra et al., 2020).
- Selective Bi‐directional Amide Bond Cleavage of N‐Methylcysteinyl Peptide: The study utilized Fmoc-Cys(Trt)-OH in exploring selective bi-directional amide bond cleavage in peptides, providing insights into controlled peptide modification. (Qiu et al., 2014).
Linkage
Analysis Note
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Cys (Trt) -OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Cys(Trt)-Cys(Trt)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Cys-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (HPLC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Protocols
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
Related Content
Introducing enhanced specifications for 20 standard Fmoc-amino acids, ensuring ≥99% HPLC purity and improved yields for high-quality peptide synthesis.
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